Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives.
نویسندگان
چکیده
A purpose-designed porphyrin-peptide hybrid effectively degraded amyloid β monomer and oligomers associated with Alzheimer's disease. Degradation was achieved using light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrid effectively neutralized the cytotoxicity of amyloid β in PC12 cells upon photoirradiation.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 67 شماره
صفحات -
تاریخ انتشار 2014